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Bernard Dugué Bernard Dugué 28 juillet 2011 10:49

Extrait du billet de SD

Mutation theory vs. aneuploidy

Duesbeg’s ar guments derive from his controversial proposal that the reigning theory of cancer — that tumors begin when a handful of mutated genes send a cell into uncontrolled growth — is wrong. He argues, instead, that carcinogenesis is initiated by a disruption of the chromosomes, which leads to duplicates, deletions, breaks and other chromosomal damage that alter the balance of tens of thousands of genes. The result is a cell with totally new traits — that is, a new phenotype.

"I think Duesberg is correct by criticizing mutation theory, which sustains a billion-dollar drug industry focused on blocking these mutations,« said Vincent, a medical oncologist. »Yet very, very few cancers have been cured by targeted drug therapy, and even if a drug helps a patient survive six or nine more months, cancer cells often find a way around it."

Chromosomal disruption, called aneuploidy, is known to cause disease. Down syndrome, for example, is caused by a third copy of chromosome 21, one of the 23 pairs of human chromosomes. All cancer cells are aneuploid, Duesberg said, though proponents of the mutation theory of cancer argue that this is a consequence of cancer, not the cause.


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